SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Screening and evaluation of cytotoxicity and antiviral effects of secondary metabolites from water extracts of Bersama abyssinica against SARS-CoV-2 DeltaArticle Published on 2022-10-262022-11-15 Journal: BMC Complementary Medicine and Therapies [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Acetate activities Analysis Anti-viral anti-viral agents antioxidant antiviral activity Antiviral effect Asthma bacterial respiratory infections Bersama abyssinica bioactive compounds bronchitis BSL-3 component Compound Concentration conducted coronavirus Coviba Dawa COVID-19 COVID-19 symptoms cytotoxicity Delta delta variant determine ether experiment fraction in vitro ingredient Isolation level 3 medication methanol Phenols polar procedure propionate Registered respiratory disorder SARS-CoV-2 Screening Secondary Metabolite Standard Tanzania temperature tested the SARS-CoV-2 Traditional Traditional medicine. treat VERO E6 cells viral pathogen virus was done was obtained water [DOI] 10.1186/s12906-022-03754-3 PMC 바로가기
Antiviral efficacy of selective estrogen receptor modulators against SARS-CoV-2 infection in vitro and in vivo reveals bazedoxifene acetate as an entry inhibitor시험관 내 및 생체 내에서 SARS-CoV-2 감염에 대한 선택적 에스트로겐 수용체 조절제의 항바이러스 효능은 진입 억제제로서 바제독시펜 아세테이트를 나타냅니다Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] Acetate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-SARS-CoV-2 antiviral efficacy Bazedoxifene bazedoxifene acetate candidate cholesterol cholesterol distribution citrate clinical Clomifene Clomifene citrate contagious coronavirus Coronaviruses Critical delta variant distribution drugs Effect Efficacy endosome acidification Estrogen estrogen receptor evaluated exhibited expression hamster hamsters human cell lines humans identify in vitro in vivo infect Infection information inhibited inhibitor interleukin-6 offer omicron Omicron variant pathogenic variant penetration Postinfection pseudovirus pseudoviruses pulmonary viral reduced reveal SARS-CoV SARS-CoV-2 SARS-COV-2 infection selective selective estrogen receptor modulator severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome coronavirus 2. Tamoxifen toremifene toremifene citrate variant Vero E6 Vero E6 cell VERO E6 cells weight loss [DOI] 10.1002/jmv.27951 PMC 바로가기 [Article Type] Article
Optimization of Anti-SARS-CoV-2 Treatments Based on Curcumin, Used Alone or Employed as a PhotosensitizerArticle Published on 2022-09-272022-11-15 Journal: Viruses [Category] SARS, 치료제, [키워드] anti-inflammatory properties Antiviral approach Cell culture cells Concentration COVID-19 Curcuma Curcumin dose effective immunomodulatory in vitro In vitro infection inhibited optimization photodynamic therapy photodynamic therapy. photosensitizer prophylactic treatment reduction reported RNase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication suggested therapy Treatment Vero E6 VERO E6 cells virion virus virus inactivation [DOI] 10.3390/v14102132 PMC 바로가기
Anisodamine potently inhibits SARS-CoV-2 infection in vitro and targets its main protease아니소다민은 시험관 내에서 SARS-CoV-2 감염을 강력하게 억제하고 주요 프로테아제를 표적으로 합니다Article Published on 2022-08-062022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory disease acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acid residue analyzed Anisodamine Antiviral antiviral activity antiviral agent cells Chinese co-cultured coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cys145 disease docking score effective drug effective drugs Gly143 H-bond HEK293 immunofluorescence assay in vitro indicated Infection inhibit M pro main protease molecular docking molecular docking studies Molecular docking study pandemic predicted protease pseudovirus entry reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suppressed target the SARS-CoV-2 therapeutic drug Traditional Chinese medicine treating COVID-19 Treatment treatment of COVID-19 Vero E6 VERO E6 cells viral infection Viral infection. [DOI] 10.1016/j.bbrc.2022.05.024 PMC 바로가기 [Article Type] Article
Treatment with metformin glycinate reduces SARS-CoV-2 viral load: An in vitro model and randomized, double-blind, Phase IIb clinical trial메트포르민 글리시네이트로 치료하면 SARS-CoV-2 바이러스 부하 감소: 시험관 내 모델 및 무작위, 이중 맹검, IIb상 임상 시험Randomized Controlled Trial Published on 2022-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] adaptive aligned Alpha caused Cell Clinical data clinical trial conducted control group coronavirus disease COVID-19 COVID-19 patients COVID-19 treatment dose doses double-blind drug effort Epsilon evaluate exposure to Health Health crisis highlight highlighting identify IIb in vitro in vitro model in vitro result in vitro study in vivo increased survival indicate inhibit metformin Metformin glycinate New coronavirus new coronavirus SARS-CoV-2 new treatment strategy new virus oxygen phase Randomized reduce reduced SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 viral SARS-CoV-2 viral load SARS-CoV-2 viral load. severe disease supplementary oxygen tested the SARS-CoV-2 therapeutic option treated Treatment Treatment effectiveness triggered variant variants of interest Vero E6 VERO E6 cells viral infection Viral load viral replication [DOI] 10.1016/j.biopha.2022.113223 PMC 바로가기 [Article Type] Randomized Controlled Trial
SARS-CoV-2 variants inactivation of plasma units using a riboflavin and ultraviolet light-based photochemical treatmentArticle Published on 2022-08-012022-11-15 Journal: Transfusion and apheresis science : official journ [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] blood product Cell cells Convalescent plasma donor COVID-19 patients Critically ill Culture experiments highlight Human plasma inactivated inactivation infect Infection infectious titer limit of detection material Neutralizing antibodies pathogen Pathogen reduction photochemical plasma Plasma transfusion therapy plasma unit reduced reducing reduction in Riboflavin RT-PCR SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 variant technology Test therapy tissue Treatment ultraviolet ultraviolet light USA UV light variants of concern. VERO E6 cells viral strain virus virus virus titer [DOI] 10.1016/j.transci.2022.103398 PMC 바로가기
Optimization and evaluation of a live virus SARS-CoV-2 neutralization assay살아있는 바이러스 SARS-CoV-2 중화 분석의 최적화 및 평가Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] 24 hour 24 hours acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added antibody application calculated cell monolayer cell suspension cells clinical isolates Coefficient of variance coronavirus correlated correlation Critical described dose ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay evaluated functional antibody response functional antibody responses growth immune evasion Immunity include Incubation period infecting Influenza Influenza virus inoculation isolates Live virus microneutralization neutralization Neutralization assay neutralization titers nucleocapsid protein optimization parameter Post-infection Precision protein level reduced replicating virus respiratory SARS-CoV-2 SARS-CoV-2 clinical isolate SARS-CoV-2 clinical isolates SARS-CoV-2 microneutralization assay SARS-CoV-2 neutralization severe acute respiratory syndrome Coronavirus the SARS-CoV-2 the strongest therapeutic Vaccine variance Vero E6 Vero E6 cell VERO E6 cells Viral Viral variants virus virus infection virus inhibition virus inoculum virus neutralization assays Virus titration was determined WHO [DOI] 10.1371/journal.pone.0272298 PMC 바로가기 [Article Type] Article
Development of a Rapid Live SARS-CoV-2 Neutralization Assay Based on a qPCR ReadoutqPCR 판독을 기반으로 한 Rapid Live SARS-CoV-2 중화 분석의 개발Article Published on 2022-07-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] antibody Antibody-mediated immunity antiviral activity calculate can be used characteristic controls correlation COVID-19 COVID-19 pandemic cross-neutralization demonstrated detect determine determined by development domain ELISA experiments faster generate gold gold standard Immunity Live virus natural infection neutralization Neutralization assay neutralization assays Neutralizing Neutralizing antibodies neutralizing antibody patient sera priority qPCR qRT-PCR Rapid Receptor-binding domain reduce reduction SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 qRT-PCR Sensitivity and specificity sera significantly standard curve Surrogate neutralization assay. tested vaccination variants Vero E6 Vero E6 cell VERO E6 cells Viral Viral load Viral RNA virus virus isolate Virus neutralization [DOI] 10.1128/jcm.00376-22 PMC 바로가기 [Article Type] Article
Persistence of infectious SARS-CoV-2 particles for up to 37 days in patients with mild COVID-19경증 COVID-19 환자에서 최대 37일 동안 전염성 SARS-CoV-2 입자 지속Article Published on 2022-07-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 치료기술, [키워드] amplified Analysis antibodies antibodies binding carried characterization characterized clade COVID-19 COVID-19 patient Diagnosis electron microscopy ELISA epitope Epitopes humoral immune response immune response immunofluorescence microscopy infected patients Infection infectious Infectious virus investigated isolate isolates lack Microscopy Mild Mutation mutations non-infectious ORF8 Patient PCR-based testing PCR-positive peptide persistence pharyngeal Pharyngeal swab quarantine RBD Receptor-binding domain remained Replication replication-competent virus RT-PCR SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles SARS-CoV2 sequence Symptom termination the receptor-binding domain Vero E6 Vero E6 cell VERO E6 cells virus virus replication WGS whole-genome sequencing Whole-genome sequencing. [DOI] 10.1111/all.15138 PMC 바로가기 [Article Type] Article